A high-fat diet is associated with changes in gut bacteria and bile acids that may increase the risk of colorectal cancer, according to a study published in the journal Cell Reports. A high-fat diet caused an increase in the number of specific intestinal bacteria in experimental mice, thereby changing the composition of bile acids. These altered bile acids trigger inflammation and affect the regeneration of intestinal stem cells, leading to more mutations and thus increasing the risk of cancer.
Ting Fu, Tao Huan, Gibraan Rahman, Michael Downes, Rob Knight, Ronald M. Evans
Published:August 22, 2023DOI: https://doi.org/10.1016/j.celrep.2023.112997